CBE Dissertation: “DNA Mediated Particle Adhesion”
CBE Dissertation: “DNA Mediated Particle Adhesion”
Advisor: John Crocker, PhD; Committee Members: Talid Sinno, PhD; Scott Diamond, PhD; and Daniel Hammer, PhD
Advisor: John Crocker, PhD; Committee Members: Talid Sinno, PhD; Scott Diamond, PhD; and Daniel Hammer, PhD
Liquid crystal elastomers are rubbery solids with liquid crystal mesogens incorporated into their main chains. They display an isotropic to nematic phase transformation accompanied by a large spontaneous deformation. This in turn leads to rich variety of phenomena including ultra-soft behavior, stripe domains, shape-morphing etc. Further, when made as slender structures, the structural instability of […]
In the first part of the presentation, we discuss a double-stranded elastic rod (birod) model and apply it to study allosteric interactions between two ligands on DNA. Next, we combine the birod model with statistical mechanics and use it to study the temperature-induced strand separation in dsDNA. Allosteric interaction between two ligands on DNA is […]
Abstract: Biomaterial implants have a long history in the clinic, but regenerative biomaterials and regenerative medicine therapies, in general, have been slow to reach patients. Clinical translation provides a unique and critical opportunity to investigate the key therapeutic drivers of technology efficacy in people. Careful evaluation of clinical outcomes and reevaluation of design parameters is […]
Two-dimensional (2D) hybrid organic-inorganic perovskites are under intense investigation due to their interesting physical properties and superior performance in thin-film based optoelectronic devices. The structural diversity embedded in the system provides a variety of parameters to target favorable properties for applications in photovoltaics (PV) and light emitting diodes (LEDs). In this talk, Dr. Mao will […]
Abstract: Mathematical Justification of Slender Body Theory Systems in which thin filaments interact with the surrounding fluid abound in science and engineering. The computational and analytical difficulties associated with treating thin filaments as 3D objects has led to the development of slender body theory, in which filaments are approximated as 1D curves in a 3D […]
The Department of Bioengineering at the University of Pennsylvania and Dr. David Meaney are pleased to announce the Doctoral Dissertation Defense of David Gabrieli. This event is open to the public.
In this talk we will review emerging applications of rarefied gas dynamics for microscale sensing, actuation and power generation. Performance of conventional fluidic devices such as pumps, combustors and heat engines decreases at the microscale due to greater viscous and heat transfer losses. Unconventional micro/nanodevices exploit the tight coupling between non-equilibrium gas, liquid and solid-state […]
High-performance designs that utilize metallic alloys are driving a need to quantify deformation in-situ at the finest length scales in order to reduce weight, increase operating temperatures, and improve fatigue life. With improvements to data reconstruction algorithms, brighter X-ray sources, and more efficient detectors, these in-situ studies of microstructural and micromechanical evolution in 3-D (nm-µm […]
Abstract: Heterogeneous catalysis is of central importance to the global economy today, facilitating the conversion of raw materials into valuable fuels and chemicals, and the abatement of chemical pollutants in an efficient way. As environmental concerns associated with the use of fossil fuels and increased viability of alternative technologies motivate a transition away from traditional […]
Thin film materials and heterostructures play a key role in modern technology including electronics and photonics. Atomically precise engineering of thin film materials enables unprecedented control of their structure and properties, bringing exciting opportunities to materials science. Transition metal dichalcogenides (TMDs), which form three-atom-thick monolayers with van der Waals surfaces, provide an ideal material platform […]
Diabetes and peripheral arterial disease affect hundreds of millions of people worldwide. Patients with these conditions frequently develop chronic wounds on the lower limbs that lead to amputation, with a 5-year mortality rate as high as 77%. Macrophages, the primary cell of the innate immune system, are critical regulators of angiogenesis and wound healing. Their […]
Abstract: We require computers that extract value from exponential data growth even as exponential transistor scaling falters. With limited scaling, power and thermal density threaten performance. Architects must pursue power efficiency in design and management. My research group addresses these challenges by integrating systems architecture with statistical inference. First, we design systems by tailoring hardware […]
This professional development workshop series is designed to provide Penn Engineering graduate students and postdocs with a richer understanding of what it is like to pursue a career in academia from those that have navigated the process successfully. Deputy Dean Kathleen J. Stebe (SEAS) will lead this extemporaneous discussion with a panel of Penn Engineering […]
Abstract: Computational modeling is an important tool to aid chemical process development. Theoretical and data-driven models can be applied both for the optimization of specific processes, and for the initial screening of potential process chemistries. I will talk about my research in advancing both of these areas. First, I will introduce the development of an […]
On the eve of the Intergovermental Panel on Climate Change (IPCC) Sixth Assessment Report, I will present a brief overview of how climate science has evolved since the publication of the Charney Report in 1979, and use a few examples from my recent work to show how one can use numerical models, observations and theories […]
Abstract Photons play a central role in many areas of quantum information science, either as qubit themselves or to mediate interactions between long-lived matter based qubits. Techniques for (1) high-fidelity generation, (2) precise manipulation and (3) ultra-efficient detection of quantum states of light are therefore a prerequisite for virtually all quantum technologies. A quantum photonic […]
Abstract: Current hardware and operating system abstractions were conceived at a time when we had minimal security threats, scarce compute and memory resources, and limited numbers of users. These assumptions are not true today. On one hand, attacks such as Spectre and Meltdown have shown that current hardware is plagued by vulnerabilities. On the other […]
Abstract: As a global society, we have been burning fossil fuels to meet our energy and transportation needs since the start of the industrial revolution. This has resulted in atmospheric CO2 concentrations much greater than at any other time during the last 650,000 years. That concentration reached a record 415 parts per million in May […]
Unique macroscopic phenomena, such as high-temperature superconductivity and colossal magnetoresistance, emerge in many complex solids due to the interplay between their electronic, magnetic, and structural degrees of freedom. This interplay also results in properties that can be tuned by manipulating their atomic structure and symmetry. In this talk, Dr. Disa will discuss two complementary “non-equilibrium” […]
Abstract: I'll discuss the use of observational data to estimate the causal effect of a treatment on an outcome. This task is complicated by the presence of 'confounders' that influence both treatment and outcome, inducing observed associations that are not causal. Causal estimation is achieved by adjusting for this confounding by using observed covariate information. I'll […]
Two-component systems (TCSs) are the largest family of signal transduction pathways in biology, and a treasure trove of biosensors for engineering applications. Though present in plants and other eukaryotes, TCSs are ubiquitous in bacteria. Bacteria use TCSs to sense everything from metal ions to carbohydrates and light, and activate responses such as biofilm formation, antibiotic-resistance, […]
Polarization is an essential behavior of living cells, yet the dynamics of this symmetry-breaking process are not fully understood. We have developed a spatial stochastic model of cellular polarization during mating of Saccharomyces cerevisiae. Specifically we investigated the ability of yeast cells to sense a spatial gradient of mating pheromone and respond by forming a […]
Abstract Light is a powerful tool for interrogating and manipulating biological systems, enabling targeted stimulation, sensing, and imaging. Optical methods such as optogenetics have transformed the study of neural circuits by making it possible to control neural activity using light. However, there remains a critical demand in research and medicine for miniaturized high resolution optical […]
The United States’ future economic growth and competitiveness depend on our capacity to innovate. Americans believe that it is possible to create jobs in the aerospace and defense industry by doing what the United States does well, which is cultivating the creativity and innovative processes developed by its people. Innovation and entrepreneurship in the aerospace […]
Abstract Personal technologies for everyday health management have the potential to transform healthcare by empowering individuals to engage in their own care, scaffolding access to critical information, and supporting patient-centered decision-making. Currently, many personal health tools often focus only on a single task or isolated event. However, chronic illnesses are characterized by information needs and […]
Abstract: Computational optimal decision-making tools are essential for ensuring that systems are designed, operated, and controlled in an economic and sustainable manner. Using optimization to make decisions for chemical and energy systems is particularly challenging due to the inherent presence of nonlinear process physics, both integer and continuous decisions, uncertainties in important parameters, and multiple […]
This professional development workshop series is designed to provide Penn Engineering graduate students and postdocs with a richer understanding of what it is like to pursue a career in academia from those that have navigated the process successfully. Deputy Dean Kathleen J. Stebe (SEAS) will lead this extemporaneous discussion with a panel of Penn Engineering […]
Solid-liquid interfaces have notoriously haphazard atomic environments. While essentially amorphous, the liquid has short-range order and heterogeneous dynamics. The crystal, albeit ordered, contains a plethora of defects ranging from adatoms to dislocation-created spiral steps. All these elements are of paramount importance in the crystal growth process, which makes the crystallization kinetics challenging to describe concisely […]
Abstract: Catalyst design is a critical pillar, and current bottleneck, in the construction of a sustainable chemical industry. Practical catalytic materials are earth-abundant, active, selective, and stable. Developing materials that meet these criteria is challenging and involves a two-phase process that (1) extracts molecular-level understanding of the origin of reactivity for a given chemical pathway, […]
Physical human-robot interaction (pHRI) aims at taking advantage of the complementary capabilities of robots and humans. One of the key challenges in pHRI is to provide a high-bandwidth human-robot interaction that is safe and intuitive for the human user. To this end, it is proposed in this work to revisit the design of robots in […]
Abstract With recent advances in state preparation, gate, and measurement operations, superconducting circuit architectures are now leading candidates for quantum information processing. As micro-fabricated circuits are scaled up towards a practical quantum processor, strict requirements on the fidelity of operations required for quantum computation are imposed. For theorists, this mandates the development of accurate models […]
Please join us on Tuesday, February 25, as we celebrate the life and legacy of Dr. Joseph Bordogna, Professor Emeritus of Electrical and Systems Engineering and former Dean of Penn Engineering. Dr. Bordogna was a student and a colleague in our school, and a beloved and visionary dean. He provided the foundational leadership for the […]
Three years ago, NSF announced Ten Big Ideas for Future Investments. From Harnessing the Data Revolution, to defining the Future of Work at the Human-Technology Frontier, and Understanding the Rules of Life, all of the Big Ideas require cross-disciplinary, convergent research to make significant progress on these important societal challenges. The talk will present an […]
Abstract: Environmental challenges and economic forces are reshaping the way we generate and consume energy on a global scale. To keep up with the accelerating adoption of electric vehicles, allow for grid scale energy storage, and meet the demands of future technological advances, new materials for high energy density batteries must be developed. High costs […]
The concept of computational materials design envisions the identification of new synthetically-accessible structures with desirable properties and the optimization of known systems using first-principles calculations. While significant steps towards realizing this vision have been made, notably in atomistic property evaluation, the computational prediction of materials synthesis and realistic structure remains a challenge. Dr. Kitchaev will […]
Abstract Across the globe, physicists in academia and industry alike are competing to be the first to build a scalable universal quantum computer. Amongst the multitudes of quantum computing architectures, solid-state quantum processors based on spins in silicon are emerging as a strong contender. Silicon is an ideal material to host spin qubits: it supports […]
Abstract: Until now, the natural world has supplied us with antibiotics. Bacteria, however, are increasingly resistant to these drugs. The next generation of antibiotics will likely come not from nature but from computer-based discovery. Working at the forefront of this development, I seek to harness computational power to find molecules with antibacterial activity. I use […]