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MEAM Seminar: “Physics-Informed Neural Networks (PINNs) for Physical Problems & Biological Problems”

Wu and Chen Auditorium (Room 101), Levine Hall 3330 Walnut Street, Philadelphia, PA, United States

We will present a new approach to develop a data-driven, learning-based framework for predicting outcomes of physical and biological systems and for discovering hidden physics from noisy data. We will introduce a deep learning approach based on neural networks (NNs) and generative adversarial networks (GANs). We also introduce new NNs that learn functionals and nonlinear […]

ESE Seminar: “Beyond Supervised Learning for Biomedical Imaging”

Smilow Center Auditorium 3400 Civic Center Blvd, Philadelphia, PA, United States

Abstract: Today, many biomedical imaging tasks, such as 3D reconstruction, denoising, detection, registration, and segmentation, are solved with machine learning techniques. In this talk, I will present a flexible learning-based framework that has allowed us to derive efficient solutions for a variety of such problems, without relying on heavy supervision. I will primarily employ image […]

BE Seminar: “High-throughput T cell repertoire profiling enabled systems immunology and immune engineering”

Room 337, Towne Building 220 South 33rd Street, Philadelphia, PA, United States

T cells are important to the initiation, prevention, and cure of many diseases. For example, various T cells based cancer immunotherapies have been quite effective in treating several types of cancers. However, a significant fraction of patients do not respond. A comprehensive understanding of the complexity of the T cells repertoire in health and diseases […]

MEAM Seminar: “Confined Curved Shells and their Elaborate Conformations”

Glandt Forum, Singh Center for Nanotechnology 3205 Walnut Street, Philadelphia, PA, United States

Curved shells, when confined, can deform to a broad assortment of large scale shapes and smaller scale wrinkling and folding patterns quite unlike what produced by their flat counterparts. The intrinsic, natural curvature of shells is the central element that allows for this rich and very interesting morphological landscape, but it is also the source […]

MEAM Seminar: “Plate Mechanical Metamaterials and their Applications”

Wu and Chen Auditorium (Room 101), Levine Hall 3330 Walnut Street, Philadelphia, PA, United States

Recently, we introduced the concept of plate mechanical metamaterials—cellular plates with carefully controlled periodic geometry and unique mechanical properties—as well as its initial realization in the form of freestanding corrugated plates made out of an ultrathin film. We used atomic layer deposition (ALD) and microfabrication techniques to make robust plates out of a single continuous […]

CBE Seminar: “Collaboration and Competition Between Active Sheets for Self-Propelled Particles”

Wu and Chen Auditorium (Room 101), Levine Hall 3330 Walnut Street, Philadelphia, PA, United States

Abstract: Biological species routinely collaborate for their mutual benefit or compete for available resources, thereby displaying dynamic behavior that is challenging to replicate in synthetic systems. Here, we use computational modeling to design microscopic, chemically active sheets and self-propelled particles encompassing the appropriate synergistic interactions to exhibit bio-inspired “feeding”, “fleeing” and “fighting”. This design couples […]

MEAM Seminar: “Liquid Crystal Elastomers”

Wu and Chen Auditorium (Room 101), Levine Hall 3330 Walnut Street, Philadelphia, PA, United States

Liquid crystal elastomers are rubbery solids with liquid crystal mesogens incorporated into their main chains. They display an isotropic to nematic phase transformation accompanied by a large spontaneous deformation. This in turn leads to rich variety of phenomena including ultra-soft behavior, stripe domains, shape-morphing etc. Further, when made as slender structures, the structural instability of […]

MEAM Doctoral Dissertation Defense: “Applications of a Double-stranded Elastic Rod Model to DNA”

4E9, DRLB 209 S. 33rd Street, Philadelphia, PA, United States

In the first part of the presentation, we discuss a double-stranded elastic rod (birod) model and apply it to study allosteric interactions between two ligands on DNA. Next, we combine the birod model with statistical mechanics and use it to study the temperature-induced strand separation in dsDNA. Allosteric interaction between two ligands on DNA is […]

Britton Chance Distinguished Lecture: “Regenerative Immunology: The Role of Technology Translation in Guiding Discovery”

Wu and Chen Auditorium (Room 101), Levine Hall 3330 Walnut Street, Philadelphia, PA, United States

Abstract: Biomaterial implants have a long history in the clinic, but regenerative biomaterials and regenerative medicine therapies, in general, have been slow to reach patients. Clinical translation provides a unique and critical opportunity to investigate the key therapeutic drivers of technology efficacy in people. Careful evaluation of clinical outcomes and reevaluation of design parameters is […]

PICS Seminar – Dr. Yoichiro Mori of the University of Pennsylvania & the University of Minnesota

PICS Conference Room 534 - A Wing , 5th Floor 3401 Walnut Street, Philadelphia, PA, United States

Abstract: Mathematical Justification of Slender Body Theory Systems in which thin filaments interact with the surrounding fluid abound in science and engineering. The computational and analytical difficulties associated with treating thin filaments as 3D objects has led to the development of slender body theory, in which filaments are approximated as 1D curves in a 3D […]