CBE Doctoral Dissertation Defense: “Exploring the Role of Hydrodynamic Interactions in Colloidal Self-Assembly” (Ying-Shuo Peng)
Abstract: Colloidal self-assembly remains difficult to predict and control, particularly in systems where experimental observations deviate from predictions based on traditional Brownian dynamics models. In these systems, hydrodynamic interactions (HI), […]
CBE Doctoral Dissertation Defense: “Engineering Interactions Among Condensed Phases of Intrinsically Disordered Proteins” (Zhihui Su)
Abstract: Proteins containing intrinsically disordered regions (IDRs) can undergo multivalent interactions that promote phase separation to form mesoscale condensates that function as membraneless organelles. As subcellular compartments, condensates hold promise […]
CBE Doctoral Dissertation Defense: “Polymer Phase Behavior Simulation Study via Deep Learning and Binding-Induced Polarization” (Dongqi Zhao)
Abstract: Polymer materials show rich phase behavior that is difficult to predict because of their structural and interaction complexity. This work develops computational tools that improve both the efficiency and […]
CBE Doctoral Dissertation Defense: “Colloidal Propulsion by a Topological Flagellum in a Nematic Liquid Crystal” (Jacky Zhang)
Abstract: Swimming, self-organization, and collective behaviors of active and driven colloids have implications in nature and applications to reconfigurable materials. Here, we focus on swimming or displacement made possible by […]
CBE Doctoral Dissertation Defense: “Configuration Matters: Unveiling Cis-Regulatory Arrangement as a Mechanism of Transcriptional Fine-Tuning” (Emilia Leyes Porello)
Abstract: The precise regulation of gene expression depends on coordinated enhancer-promoter (E-P) interactions, yet the principles governing how enhancer configuration influences transcription remain unclear. Classical models describe enhancers as modular […]
CBE Doctoral Dissertation Defense: “Exploring Liquid-Liquid Phase Separation Across Length Scales: From Atomistic Bias Potentials To Phase-Field Models” (Alexander M. Johnson)
Abstract: Liquid–liquid phase separation is a fundamental thermodynamic process that governs structure and function in biological systems, chemical separations, and multiphase materials. Within this broad field, computational studies play a […]
CBE Doctoral Dissertation Defense: “Mechanical Confinement as a Driver of Aneuploidy in Cancer” (Steven Phan)
Abstract: Cell confinement and mechanical stress are common in solid tumors, but any impact on genetic changes remains unclear. Using chromosome reporters (ChReporters) that reveal heritable losses of chromosomes in […]
CBE Doctoral Dissertation Defense: “DROPS-ON-STILTS MICROROBOTS FOR TRANSPORT AND DELIVERY OF HYDROPHOBIC CARGO” (Oluwafemi Ligan)
Abstract: Magnetically actuated microrobots composed of dynamic assemblies of iron oxide nanoparticles (IONPs) offer versatile opportunities for biomedical applications. While such assemblies can reconfigure and perform diverse tasks under applied […]
CBE Doctoral Dissertation Defense: “Gas Encapsulating Microcapsules (GEMs)” (CK Yeh)
Abstract: Microcapsules that can respond under hydrostatic pressure would open a new avenue of application in ultrasound- or impact-induced release of therapeutic agents. While microcapsules that are designed to release […]
CBE Seminar: “Imaging Genetics: Enhancer-mediated Dynamic Gene Control in Space and Time” (Bomyi Lim, University of Pennsylvania)
Abstract: Canonical models suggest that regulatory enhancers function independently of genomic distance, position, and orientation to activate the target gene. Indeed, a wide range of genomic distances and relative enhancer […]