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Herman P. Schwan Distinguished Lecture: “Engineering Proteins, Genomes, Viruses & Organs” (George Church, Harvard & MIT)

Zoom

Our exponential technologies for reading, writing genomes and epigenomes combined with AI-ML has enabled large libraries and selections for radical new functions — e.g. resistance to all viruses, novel delivery vectors for gene therapies, xeno-transplantation, de-extinction, and de-aging. This lecture will be held remotely. Zoom Link: https://upenn.zoom.us/j/94497096918?pwd=5qeoyMcmEyDboMW3bKgSCmWKYBMCbP.1  

BE Seminar – “Engineering cell state-specific gene regulation with AI and synthetic biology” (Sebastián Castillo Hair, University of Washington)

Cells across tissues, developmental stages, and disease conditions adopt distinct intracellular states – epigenomic, transcriptomic, and proteomic profiles – to compartmentalize function in time and space. The ability to write DNA- and RNA-encoded programs that sense and interface with cellular states has transformative potential for biotechnology, for example in designing gene therapies with cell type- […]

BE Seminar – “Engineered bacteria for cancer therapy” (Tal Danino, Columbia University)

Berger Auditorium (Room 13), Skirkanich Hall 210 South 33rd Street, Philadelphia, PA, United States

Synthetic biology is driving a new era of medicine through the genetic programming of living cells. One particular focus has been the engineering of bacteria as therapeutic delivery systems for cancer, where microbes colonize and release payloads within tumors. Here, genetic circuits are designed to enhance spatial and temporal control of microbial behaviors for improved […]

MEAM Seminar: “Miniaturized Robots and Probes for Precision Health”

Wu and Chen Auditorium (Room 101), Levine Hall 3330 Walnut Street, Philadelphia, PA, United States

Designing miniaturized robots and bioelectronic devices will enable access throughout the entire human body, leading to novel procedures at the cellular level and offering localized diagnosis and treatment with unprecedented precision and efficiency. However, the soft, complex, and multi-dimensional nature of biological systems poses significant challenges for mechanical design, manufacturing, materials engineering, and functional integration […]

CBE & BE Seminar: “Targeting the Brain and Behavior to Probe the Dynamics of Aging” (Claire Bedbrook, Stanford University)

Wu & Chen Auditorium

Bio & Abstract: Claire Bedbrook is an engineer and neuroscientist working to extend lifespan by modulating the brain. Claire was trained in chemical engineering at the University of California, Berkeley. She completed her Ph.D. in Bioengineering at the California Institute of Technology with Professor Frances Arnold and Professor Viviana Gradinaru, where she engineered molecular tools […]

BE Seminar – “Scaffold-Modulated Healing in Irradiated Bone” (Katie Hixon, Dartmouth Engineering)

Berger Auditorium (Room 13), Skirkanich Hall 210 South 33rd Street, Philadelphia, PA, United States

Bone is the third most common site for cancer metastasis, affecting ~66% of patients with common cancers—breast, lung, prostate, renal, thyroid—incurring skeletal events in up to 400,000 people in the US/year. Metastatic bone disease (MBD) results in weakened bone, leading to refractory pain and pathological fracture that increase disease state morbidity. Despite bone tissue’s dynamic […]

MEAM Seminar: “Exploring Structure, Mechanics, and Function in Soft Biological Systems Across Scales”

Raisler Lounge (Room 225), Towne Building 220 South 33rd Street, Philadelphia, PA, United States

Soft biological systems exhibit intricate hierarchical organization, with structures spanning multiple length scales, from tissues to cells and molecules. This structural complexity gives rise to rich mechanical behaviors that profoundly influence biological function. My research integrates soft matter physics and biology to establish a unified framework that connects structure, mechanics, and function in soft biological […]

MEAM Seminar: “Three-Dimensional Biointerfaces: Soft Bioelectronics for Complex Biological Geometries”

Wu and Chen Auditorium (Room 101), Levine Hall 3330 Walnut Street, Philadelphia, PA, United States

Cutting-edge biological and medical research demands innovative methods for sensing and modulating complex tissues, organs, and organ systems. Recent progress in bioelectronics enables multimodal interfacing for broad fundamental and therapeutic applications. However, key challenges persist in interfacing with complex biological geometries, particularly for applications requiring conformal contact in electrical, chemical, or mechanical biointerfaces. In this […]

Celebration of Community

Wu and Chen Auditorium (Room 101), Levine Hall 3330 Walnut Street, Philadelphia, PA, United States

The Cora Ingrum Center for Community and Outreach is planning its annual Celebration of Community gala to showcase Penn Engineering students, staff, and faculty in their multi-talented richness. The event will consist of guest speakers, performances, presentations from student groups, and a variety of cuisines. Do not hesitate to contact Dr. Ocek Eke (ocek@seas.upenn.edu) and […]