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September 2020
BE Seminar: “Patients, Providers and Data: How the EMR and Data Science are Changing Clinical Care” (Kevin Johnson)
This event will be held virtually via zoom. Check your email for the link and passcode or contact ksas@seas.upenn.edu. The electronic health record (EHR) is a powerful application of Systems Engineering to healthcare. It is a byproduct of a host of pressures including cost, consolidation of providers into networks, uniform drivers of quality, and the need for timely care across disparate socioeconomic and geographic landscapes within health systems. The EHR is also a fulcrum for innovation and one of the…
Find out more »October 2020
BE Seminar: “Predicting the effects of engineering immune cells using systems biology modeling” (Stacey Finley)
This event will be held virtually on zoom. Check your email for the link and passcode or contact ksas@seas.upenn.edu. Systems biology approaches, including computational models, provide a framework to test biological hypotheses and optimize effective therapeutic strategies to treat human diseases. In this talk, I present recent work in modeling signaling in cancer-targeting immune cells, including CAR T cells at Natural Killer cells. Chimeric antigen receptors (CARs) are comprised of a variety of different activating domains and co-stimulatory domains that…
Find out more »PSOC Webinar: “The DNA Damageome and Cancer” (Susan Rosenberg)
“The DNA Damageome and Cancer” Physical Sciences in Oncology Center PSOC@Penn Fall 2020 Webinar Series Mondays @ Noon (EST) For webinar links, please contact manu@seas.upenn.edu
Find out more »BE Seminar: “Imaging and sequencing single cells” (Aaron Streets)
This event will be held virtually on zoom. Check your email for the link and passcode or contact ksas@seas.upenn.edu. Recent advances in microfluidics and high-throughput sequencing technology have enabled rapid profiling of genomic material in single cells. Valve- and droplet-based microfluidic platforms can precisely and efficiently manipulate, sort, and process cells to generate indexed sequencing libraries, allowing for high-throughput single-cell analysis of the genome, transcriptome, proteome, and epigenome. Such technology has been instrumental in the global effort to create a…
Find out more »PSOC Webinar: “Manipulating Macrophage Signaling” (Meghan Morrissey)
"Manipulating Macrophage Signaling - How macrophages measure 'Eat me' and 'Don't eat me' signals" Physical Sciences in Oncology Center PSOC@Penn Fall 2020 Webinar Series Mondays @ Noon (EST) For webinar links, please contact manu@seas.upenn.edu
Find out more »PSOC Webinar: “A three dimensional extracellular matrix supports organoid phenotype by reducing cortical actin tension to maintain endoplasmic reticulum function” (FuiBoon Kai)
“A three dimensional extracellular matrix supports organoid phenotype by reducing cortical actin tension to maintain endoplasmic reticulum function” Physical Sciences in Oncology Center PSOC@Penn Fall 2020 Webinar Series Mondays @ Noon (EST) For webinar links, please contact manu@seas.upenn.edu
Find out more »MEAM Seminar: “Engineering Solutions for Tough Problems in Trauma: From Occlusion Balloons to Decision-Support”
Acute hemorrhage and hemorrhagic shock result in approximately 60,000 annual deaths in the United States. The vast majority of these deaths are in severely injured patients, but experts in trauma care believe many of these deaths can actually be prevented. Efforts focused on injury prevention and pre-emptive intervention have produced some improvements in survival. However, for those who sustain severe injuries, a range of engineering solutions could mitigate the risk of death from hemorrhage. In this talk, I will review…
Find out more »BE Seminar: “High-throughput Screening of a Combinatorial CAR Co-stimulatory Domain Library” (Kyle Daniels)
This event will be held virtually on zoom - details coming soon. CAR T cells—T cells engineered to express a chimeric antigen receptor that redirects their function to a specific antigen—have proven to be an effective therapy for certain B cell cancers, but many issues remain in order to apply CAR T cells to a broader range of cancers. The activity of CAR T cells can be modulated by varying their co-stimulatory domains. Most CARs use co-stimulatory domains from natural…
Find out more »PSOC Webinar: Joel Bader
Talk title TBC Physical Sciences in Oncology Center PSOC@Penn Fall 2020 Webinar Series Mondays @ Noon (EST) For webinar links, please contact manu@seas.upenn.edu
Find out more »November 2020
PSOC Webinar: Emily Hatch
Talk title TBC Physical Sciences in Oncology Center PSOC@Penn Fall 2020 Webinar Series Mondays @ Noon (EST) For webinar links, please contact manu@seas.upenn.edu
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