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January 2020

BE Seminar: “High-throughput T cell repertoire profiling enabled systems immunology and immune engineering”

January 9, 2020 at 12:00 PM - 1:00 PM
Room 337, Towne Building, 220 South 33rd Street
Philadelphia, PA 19104 United States
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T cells are important to the initiation, prevention, and cure of many diseases. For example, various T cells based cancer immunotherapies have been quite effective in treating several types of cancers. However, a significant fraction of patients do not respond. A comprehensive understanding of the complexity of the T cells repertoire in health and diseases not only provide underlying mechanisms but also new therapeutic targets. In the past several years, we have developed several tools to profile the T cell…

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February 2020

BE Seminar: “Immunomodulatory Biomaterials for Limb Salvage”

February 6, 2020 at 12:00 PM - 1:00 PM
Room 337, Towne Building, 220 South 33rd Street
Philadelphia, PA 19104 United States
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Diabetes and peripheral arterial disease affect hundreds of millions of people worldwide. Patients with these conditions frequently develop chronic wounds on the lower limbs that lead to amputation, with a 5-year mortality rate as high as 77%. Macrophages, the primary cell of the innate immune system, are critical regulators of angiogenesis and wound healing. Their dysfunction is strongly implicated in arterial dysfunction, limb ischemia, and poorly healing chronic wounds. The goal of the Biomaterials and Regenerative Medicine Laboratory at Drexel…

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