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BE Seminar Series: Heterogeneous, Multi-Scale and Patient-Speci C Pharmacodynamic Systems Models for Cancer with Clinical Applications

Room 337, Towne Building 220 South 33rd Street, Philadelphia, PA, United States

Abstract: Systems models of key signaling pathways in cancer have been extensively used to understand and explore the mechanisms of action of drugs and growth factors on cancer cell signaling. In general, such models predict the effect of mechanical or chemical stimuli (for e.g. drug dosage) in terms of activity of one or more key […]

MEAM Seminar: “Additive Manufacturing and Architected Materials”

Wu and Chen Auditorium (Room 101), Levine Hall 3330 Walnut Street, Philadelphia, PA, United States

Material properties are governed by the chemical composition and spatial arrangement of constituent elements. Over the past decade, the field of architected materials has sought to design, fabricate, and demonstrate materials with performance that is fundamentally controlled by geometry at multiple length-scales rather than chemical composition alone. There have been many advancements ranging from the […]

PICS Seminar: “Topology, Geometry, and Fracture in Networked Materials: A Tale of Scales”

Raisler Lounge (Room 225), Towne Building 220 South 33rd Street, Philadelphia, PA, United States

The skeleton of many natural and artificial structures may be abstracted as networks of nonlinearly interacting elements. Examples include rubber, gels, soft tissues, and lattice materials. Understanding the multiscale nature of deformation and failure of networked structures hold key for uncovering origins of fragility in many complex systems including biological tissues and enables designing novel […]

BE Seminar: Next Generation Orthobiologics: Advanced Growth Factor and Biomaterials Engineering

Class of 62 Auditorium, John Morgan Building 3620 Hamilton Walk, Philadelphia, PA

The standard of care for augmenting surgical bone repair or regeneration remains bone graft harvested from the patient despite a lack of sufficient quantity or quality of graft in many clinical cases.  Bone morphogenetic protein (BMP) therapeutics have been successfully developed and commercially marketed as substitutes for bone graft.  Although the clinical success of BMP, […]