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MEAM Seminar: “Force, Shape, and Motion in Collective Cell Migration”

Wu and Chen Auditorium (Room 101), Levine Hall 3330 Walnut Street, Philadelphia, PA, United States

Cells migrate collectively to form tissues, to heal wounds, and, in cancer, to metastasize. During these biological processes, the collective migration exhibits a transition from a solid-like state, wherein cell positions remain fixed, to a fluid-like state, wherein cells flow freely and rearrange their positions with their neighbors. Recent mechanics-based models and experiments have demonstrated […]

BE Seminar Series: Applied Topology in Biological Systems

Room 337, Towne Building 220 South 33rd Street, Philadelphia, PA, United States

Though rooted in pure mathematics, algebraic topology has recently enabled novel analysis techniques for biological data. Specifically, the method called persistent homology which employs ideas from topology to characterize the voids in a complex network. In this talk, I will briefly introduce persistent homology and give an overview of how we have recently applied this […]

BE Seminar Series: Synchronization is Robust in a Computational Model of Neuronal Network Dynamics and Injury

Room 337, Towne Building 220 South 33rd Street, Philadelphia, PA, United States

At the macroscale, synchronization between brain regions is believed to be important for memory and attention. Injury, including mild traumatic brain injury, can both increase and decrease synchronization as measured by functional MRI, but these changes are not well understood and are unknown at a smaller spatial scale. Here, we examined how injury affects the […]

BE Seminar Series: Heterogeneous, Multi-Scale and Patient-Speci C Pharmacodynamic Systems Models for Cancer with Clinical Applications

Room 337, Towne Building 220 South 33rd Street, Philadelphia, PA, United States

Abstract: Systems models of key signaling pathways in cancer have been extensively used to understand and explore the mechanisms of action of drugs and growth factors on cancer cell signaling. In general, such models predict the effect of mechanical or chemical stimuli (for e.g. drug dosage) in terms of activity of one or more key […]

MEAM Seminar: “Additive Manufacturing and Architected Materials”

Wu and Chen Auditorium (Room 101), Levine Hall 3330 Walnut Street, Philadelphia, PA, United States

Material properties are governed by the chemical composition and spatial arrangement of constituent elements. Over the past decade, the field of architected materials has sought to design, fabricate, and demonstrate materials with performance that is fundamentally controlled by geometry at multiple length-scales rather than chemical composition alone. There have been many advancements ranging from the […]

PICS Seminar: “Topology, Geometry, and Fracture in Networked Materials: A Tale of Scales”

Raisler Lounge (Room 225), Towne Building 220 South 33rd Street, Philadelphia, PA, United States

The skeleton of many natural and artificial structures may be abstracted as networks of nonlinearly interacting elements. Examples include rubber, gels, soft tissues, and lattice materials. Understanding the multiscale nature of deformation and failure of networked structures hold key for uncovering origins of fragility in many complex systems including biological tissues and enables designing novel […]