BE Seminar: “Engineering Stem Cells to Create Novel Delivery Vehicles”
Synthetic biology has transformed how cells can be reprogrammed, providing a means to reliably and predictably control cell behavior with the assembly of genetic parts into more complex gene circuits. Using approaches and tools in synthetic biology, we are programming stem cells with novel genetic tools to control genes and pathways that result in changes […]
MEAM Seminar: “Multiscale Interactions in Multiphase Turbulent Flows: Fundamentals to Applications”
Recent advances in experimental measurements and numerical simulations has allowed us to discover new phenomena in multiphase turbulence (a flow regime characterized by chaotic and irregular motion in the presence of immersed surfaces/bodies). In this talk, I will discuss some of these new discoveries and their importance both from a fundamental and an application viewpoint. […]
BE Seminar: “Musculoskeletal Tissue Engineering”
MEAM Seminar: “Cell Polarization and Growth”
Polarization is an essential behavior of living cells, yet the dynamics of this symmetry-breaking process are not fully understood. We have developed a spatial stochastic model of cellular polarization during mating of Saccharomyces cerevisiae. Specifically we investigated the ability of yeast cells to sense a spatial gradient of mating pheromone and respond by forming a […]
BE Seminar: “Repurposing bacterial two-component systems as sensors for synthetic biology applications “
Two-component systems (TCSs) are the largest family of signal transduction pathways in biology, and a treasure trove of biosensors for engineering applications. Though present in plants and other eukaryotes, TCSs are ubiquitous in bacteria. Bacteria use TCSs to sense everything from metal ions to carbohydrates and light, and activate responses such as biofilm formation, antibiotic-resistance, […]
BE Seminar: “Immunomodulatory Biomaterials for Limb Salvage”
Diabetes and peripheral arterial disease affect hundreds of millions of people worldwide. Patients with these conditions frequently develop chronic wounds on the lower limbs that lead to amputation, with a 5-year mortality rate as high as 77%. Macrophages, the primary cell of the innate immune system, are critical regulators of angiogenesis and wound healing. Their […]
Thesis Defense: “Multiscale Predictions of Mechanical Response and Computational Circuit Dynamics After Traumatic Brain Injury”
The Department of Bioengineering at the University of Pennsylvania and Dr. David Meaney are pleased to announce the Doctoral Dissertation Defense of David Gabrieli. This event is open to the public.
Thesis Defense: “Transcriptional Control of Endothelial Cell Motility, Extracellular Matrix Sensing, and Vasculogenesis”
The Department of Bioengineering at the University of Pennsylvania and Dr. Joel Boerckel are pleased to announce the Doctoral Dissertation Defense of Devon E. Mason. This event is open to the public.
BE Seminar: “High-throughput T cell repertoire profiling enabled systems immunology and immune engineering”
T cells are important to the initiation, prevention, and cure of many diseases. For example, various T cells based cancer immunotherapies have been quite effective in treating several types of cancers. However, a significant fraction of patients do not respond. A comprehensive understanding of the complexity of the T cells repertoire in health and diseases […]