CBE

The ability to modulate pathogenic proteins represents a powerful treatment strategy for diseases. Unfortunately, many proteins are considered "undruggable" by small molecules, and are often intrinsically disordered, precluding the usage of structure-based tools for binder design. To address these challenges, we have developed a suite of algorithms that enable the design of target-specific peptides via […]

One of the most intriguing outcomes of casting our thinking about the world around us in mathematical terms is that phenomena that were thought to be quite distinct are instead revealed as being the “same.” Thinkers as long ago as Pliny the Elder made observations on active matter noting: "It is a peculiarity of the […]

Holistic imaging of diverse functional, anatomical, and molecular architecture that span multiple levels, from cells to an entire system, remains a major challenge in biology. In this talk, I will introduce a series of technologies that enable integrated multiscale imaging and molecular phenotyping of both animal tissues and human clinical samples. I will discuss how […]