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BE Seminar: “Probing Metabolism Across Scales” (Yihui Shen, Princeton University)

Raisler Lounge (Room 225), Towne Building 220 South 33rd Street, Philadelphia, PA, United States

Metabolism supports the biosynthetic and energetic demand of all living creatures. Over decades, we have accumulated knowledge of how individual enzymes work in vitro, but we don’t have a good sense about how they work together in vivo. Thus, fundamental to our understanding of metabolic operation is the ability to measure metabolic activity in vivo. […]

Spring 2023 GRASP on Robotics: Rodney Brooks, Robust.AI, “Academic research: exploration vs exploitation”

Wu and Chen Auditorium (Room 101), Levine Hall 3330 Walnut Street, Philadelphia, PA, United States

This is a hybrid event with in-person attendance in Wu and Chen and virtual attendance via Zoom. This week's presenter will be in-person as well.    ABSTRACT Intelligent action is critical in robotics, more so than much of AI where results are often mediated by humans in the loop. That said, robotics also needs to […]

MEAM Seminar: “Data-Aware Computational Models for Science and Engineering”

Wu and Chen Auditorium (Room 101), Levine Hall 3330 Walnut Street, Philadelphia, PA, United States

In the past half-century, partial differential equation (PDE)-based computational models have emerged as indispensable for science and engineering. However, remarkable gaps still exist between state-of-the-art simulations and reality, meaning that many simulations are ineffective in supporting decision-making or design under uncertainty for complex systems (e.g., Mars landing). To bridge the gap and fulfill challenging real-world […]

ASSET Seminar: Decision-Aware Learning for Global Health Supply Chains, Osbert Bastani (University of Pennsylvania)

Levine 307 3330 Walnut Street, Philadelphia, PA, United States

Abstract: Machine learning algorithms are increasingly used in conjunction with optimization to guide decision making. A key challenge is aligning the machine learning loss with the decision-making loss. Existing solutions have limited flexibility and/or scale poorly to large datasets. We propose a principled decision-aware learning algorithm that uses a Taylor expansion of the optimal decision […]

CBE Seminar Series: “A New Phase of Biological Controls: A Design Framework for Programmable Synthetic Biomolecular Condensates and the Mechanisms of a Functional Liquid-Liquid Interface” (Yifan Dai, Duke University)

Wu and Chen Auditorium (Room 101), Levine Hall 3330 Walnut Street, Philadelphia, PA, United States

Abstract: A fundamental question in nature is how the cellular processes are organized with sequential and spatial precision in a dynamic and densely packed environment. Evidence is now mounting that biomolecular condensation, a demixing process mediated by phase separation coupled with percolation, dictates the organization principles of cellular biochemistry. From the perspective of synthetic biology, […]

BE Seminar: “Programming multicellular interactions and organization using synthetic cell adhesion molecules” (Adam Stevens, UCSF)

Glandt Forum, Singh Center for Nanotechnology 3205 Walnut Street, Philadelphia, PA, United States

Cell adhesion molecules (CAMs) are ubiquitous in multicellular organisms and specify precise cellular interactions in processes as diverse as tissue development and immune cell trafficking. We have generated an array of synthetic CAMs by combining orthogonal extracellular interactions with native intracellular domains. Diverse homotypic or heterotypic extracellular binding domains specify the connectivity between cells, while […]

Spring 2023 GRASP on Robotics: Jeremy D. Brown, Johns Hopkins University, “Understanding the Utility of Haptic Feedback in Telerobotic Devices”

Wu and Chen Auditorium (Room 101), Levine Hall 3330 Walnut Street, Philadelphia, PA, United States

This is a hybrid event with in-person attendance in Wu and Chen and virtual attendance via Zoom. This week's presenter will be in-person as well.    ABSTRACT The human body is capable of dexterous manipulation in many different environments. Some environments, however, are challenging to access because of distance, scale, and limitations of the body […]

CBE Seminar Series: “Engineered CRISPR Systems for Disease Treatment and Diagnostics” (Xue Sherry Gao, Rice University)

Glandt Forum, Singh Center for Nanotechnology 3205 Walnut Street, Philadelphia, PA, United States

Abstract: The recent discovery of the CRISPR genome editing systems has been revolutionizing both basic biological research and the treatment of human genetic disorders. However, there are remaining challenges in improving the precision and multiplexity of the current CRISPR systems for genome manipulation. In this seminar, I will overview our recent development of highly specific […]

MEAM Seminar: “Leveraging Unsteady Flows for Enhanced Performance in Wind-Energy Systems”

Wu and Chen Auditorium (Room 101), Levine Hall 3330 Walnut Street, Philadelphia, PA, United States

Wind energy is poised to play a considerable role in the global transition to clean-energy technologies within the next few decades. Modern wind turbines, like aircraft and other aerodynamic structures, are typically designed with the assumption that the flows they encounter will be uniform and steady. However, atmospheric flows are highly unsteady, and systems operating […]