This event will be held virtually on zoom. Check email for zoom link or email ksas@seas.upenn.edu. CAR T cells—T cells engineered to express a chimeric antigen receptor that redirects their function to a specific antigen—have proven to be an effective therapy for certain B cell cancers, but many issues remain in order to apply CAR […]
Abstract: Fluids and solids tend to be addressed using distinct computational perspectives. Solid deformation is most commonly simulated with Lagrangian finite-element methods, whereas fluid flow is amenable to Eulerian-frame approaches such as finite difference and finite volume methods. Problems that mix fluid and solid behaviors simultaneously present interesting numerical challenges. Here we focus on […]
Talk title TBC Physical Sciences in Oncology Center PSOC@Penn Fall 2020 Webinar Series Mondays @ Noon (EST) For webinar links, please contact manu@seas.upenn.edu
In this talk I will provide an overview of our recent work in data-driven methods---mainly machine learning---to enhance computational materials physics models. This body of work has proceeded along two main fronts. The first is system inference, where we seek to identify physical mechanisms via their mathematical signatures as differential or algebraic operators. Our approach […]
With the commercialization of wide-bandgap power semiconductors, multi-MHz switching frequencies are more compelling and critical to meet new applications demanding leaps in power density and efficiency. In the past, studies of these converters reported significant gaps between measured and modeled performance, often attributed to dynamic RDS,ON in GaN HEMTs. In particular, the power semiconductors – […]
Abstract Until now, the natural world has supplied us with antibiotics. Bacteria, however, are increasingly resistant to these drugs. The next generation of antibiotics will likely come not from nature but from computer-based discovery. Computer-driven approaches have the potential to outperform humans, as demonstrated for pattern recognition of images and text. In order for machines […]
Two fundamental challenges that arise in the development of air-breathing supersonic combustion ramjet engines (scramjets) for hypersonic flight are: 1) the rapid mixing of fuel and oxidizer that must occur prior to combustion, and 2) the coupling between the engine structure and the flow dynamics. Interactions of shock waves and turbulence that characterize the flow […]
Talk title TBC Physical Sciences in Oncology Center PSOC@Penn Fall 2020 Webinar Series Mondays @ Noon (EST) For webinar links, please contact manu@seas.upenn.edu
Robots often struggle to move through complicated environments from cluttered living spaces to treetop canopies where humans and animals flit with ease. Jumping is an exciting locomotion mode that can enable small ground-based robots to maneuver around large obstacles and gaps in complicated environments. A high-power jumping robot can rapidly traverse obstacles, but the resulting […]
Abstract The emergence of coordinated cellular, tissue, and organismal responses rely on complex biological networks. While the connectivity of the networks is increasingly defined, understanding the dynamics of the system and the emergence of coordinated responses at multiple spatial and temporal scales is an unsolved problem in many systems. This is a challenge addressed by […]
