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MEAM Seminar: “Magnetic Fluid Hyperthermia with Magnetic Iron Oxide Nanoparticles: A Case Study in Multi-disciplinary Translational Biomedical Research”
November 14, 2023 at 10:00 AM - 11:30 AM
Magnetic nanoparticles that are responsive to clinically safe magnetic fields offer multi-modal nanomedicine capabilities. To succeed, complexities of physics and engineering must be addressed to match physical and magnetic properties of magnetic nanoparticles with devices used to activate them. This requires thoughtful design and fabrication of both nanoparticles and devices, with appropriate testing in relevant biological models that faithfully represent intended end use. Hyperthermia is a heat-based cancer therapy that improves treatment outcomes and patient survival when controlled energy delivery is combined with accurate thermometry. To date, few technologies have achieved the needed evolution for the demands of the clinic. Magnetic fluid hyperthermia (MFH) offers this potential, but to be successful it requires particle-imaging technology that provides real-time thermometry. Presently, the only technology having the potential to meet these requirements is magnetic particle imaging (MPI), for which a proof-of-principle demonstration with MFH has been achieved. Successful clinical translation and adoption of integrated MPI/MFH technology demands successful integration of imaging data processing with robust computational heat-transfer modeling and adaptive temperature control algorithms into a theranostic device platform.
Robert Ivkov
Professor, Departments of Radiation Oncology and Molecular Radiation Sciences, Oncology, Materials Science and Engineering, and Mechanical Engineering, The Johns Hopkins University School of Medicine
Dr. Ivkov is a Professor in the Department of Radiation Oncology and Molecular Radiation Sciences at the Johns Hopkins School of Medicine. He holds joint appointments in the Department of Oncology at the Sydney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine; Department of Mechanical Engineering, and the Department of Materials Science and Engineering, both in the Whiting School of Engineering at Johns Hopkins University. He also holds a Guest Researcher position at the National Institute of Standards and Technology’s (NIST) Center for Neutron Research (NCNR) in Gaithersburg, MD. Upon his arrival to the Department of Radiation Oncology and Molecular Radiation Sciences at The Johns Hopkins University School of Medicine in early 2008, Dr. Ivkov began a program developing magnetic nanoparticles and devices that exploit magnetic hysteresis to generate therapeutic heat in models of human cancer. More recently, his research focus has expanded to include effects of systemic exposure to nanoparticles, and local thermal therapy combinations on systemic anti-cancer immune responses. He has published over 100 scientific papers, patents (issued and pending) in nanotechnology, nanobiotechnology, materials science, magnetic devices, colloid and interface science, neutron scattering, and targeted cancer therapy. He currently serves as Nanotechnology Section Editor of the International Journal of Hyperthermia.