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ESE Spring Seminar – “Advancing Precision Medicine and Precision Health with CMOS-enabled Continuous Monitoring of Molecules, Cells, and Beyond”
March 22, 2022 at 11:00 AM - 12:00 PM
“Continuous” monitoring of specific biomarkers in real-time offers longitudinal information that can enable not only rapid medical decision-making but also early disease detection. As opposed to the current end-point diagnostics approaches, such a continuous-monitoring capability introduces a new dimension in achieving precision medicine and precision health. In this talk, I will present my research contributions toward this goal. Specifically, my research harvests the power of CMOS integrated circuits, applied physics, and advanced biotechnology to address biosensing requirements on sensitivity, specificity, throughput, multiplexing, device miniaturization, and system scaling. I will focus on two developed technology platforms: (1) an electrochemical-sensing wireless implant for in vivo monitoring of small molecules using reagentless structure-switching “aptamers” and (2) a cytometry-on-CMOS platform for high-throughput studies of the electromagnetic signatures at GHz frequencies. The former has broad applications including precision drug dosing and early disease detection whereas the later has the potentials for sensing circulating-tumor-cells in blood. I will address their critical needs as well as circuits and systems design challenges. I will also present my recent activity in developing high-resolution intraoperative imaging tools, circuit techniques to overcome density constraints in neural-recording probes, sensing platform for “distributed” diagnosis, and low-power heart-rate-sensing wearables.
Jun-Chau Chien
Assistant Professor in Electrical Engineering, National Taiwan University
Jun-Chau Chien received the B.S. and M.S. degrees from National Taiwan University in 2004 and 2006, and Ph.D. degree from University of California, Berkeley, in 2015. He received the postdoctoral training from 2017–2018 at Stanford University and served as a Research Engineer from 2018-2021, also at Stanford University. He moved to National Taiwan University in February 2021 and is currently an Assistant Professor at Department of Electrical Engineering. He held industrial positions at Xilinx, InvenSense, LifeSignal, and INanoBio in 2012, 2015, 2017, and 2020, respectively. His research focuses on CMOS-based microsystems for in vitro and in vivo biosensing and high-speed millimeter-wave and mixed-signal circuits and systems.
He was the recipient of the 2019 CICC Outstanding Regular Paper Award, the 2014 Microwave Theory and Techniques Society (MTT-S) Graduate Fellowship for Medical Applications, the 2014 Solid-State Circuit Society (SSCS) Predoctoral Achievement Award, the 2013–2014 Outstanding Graduate Student Instructor Award of the University of California at Berkeley, the 2014 Analog Devices Outstanding Design Award, the 2008 Berkeley Wireless Research Center Fellowship, the 2007 International Solid-State Circuits Conference (ISSCC) Silk Road Award, and the 2006 Outstanding Research Award and Annual Best Thesis Award of the Graduate Institute of Electronics Engineering, National Taiwan University. He was a co-recipient of the 2010 ISSCC Jack Kilby Award for Outstanding Student Paper for his work on a 90 GHz pulser with 30 GHz of bandwidth for medical imaging.