BE Seminar: “DNA microscopy in two and three dimensions” (Joshua Weinstein, University of Chicago)
October 17 at 3:30 PM - 4:30 PM
Lymphatic, nervous, and tumoral tissues, among others, exhibit physiology that emerges from three-dimensional interactions between genetically unique cells. Technologies capable of volumetrically imaging transcriptomes, genotypes, and morphologies in a single de novo measurement can provide a critical lens into the biological complexity of living systems. We present experimental and computational work to develop DNA microscopy: a modality of imaging that captures physical images of specimen genetic content using a massive distributed network of DNA molecules inside it. We demonstrate DNA microscopy in two-dimensional cell cultures and genome-wide in intact zebrafish embryos.
Joshua Weinstein, Ph.D.
Assistant Professor, Department of Medicine Section of Genetic Medicine, Pritzker School of Molecular Engineering, University of Chicago
Joshua Weinstein completed his PhD in biophysics at Stanford University and his undergraduate studies at the University of Pennsylvania. His research interests include developing DNA-based technologies for high-throughput encoding and decoding of biological information, as well as statistical models of multicellular systems. He was a 2020 Moore Inventor Fellow and 2021 Damon Runyon-Rachleff Innovator, and is currently Assistant Professor in the Departments of Medicine and Molecular Engineering at the University of Chicago.