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Abstract: In modern engineering, sustainability is a crucial aspect, especially in chemical and biological process systems. This concept has evolved to encompass a holistic approach, emphasizing not only the use of sustainable resources but also the development of systems that are environmentally friendly, smart, and efficient. Such systems aim to minimize waste and optimize resource […] |
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Abstract Invasive biopsy is the gold standard for diagnosing several diseases; however, these procedures offer a limited, localized view of the disease pathology to the physician and are not risk-free to the patient. Cell-free RNA (cfRNA) in blood plasma reflects dynamic gene expression changes and can facilitate early disease diagnosis, yet current cfRNA assays fall […] |
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Abstract The demand for viral vectors is poised to soon exceed current production capacities, driven by the surging number of clinical trials for gene and cell therapies. Unfortunately, current manufacturing processes for viral vectors have high costs and low titers. This talk will demonstrate how process systems engineering tools can be leveraged for addressing the […] |
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Abstract Neuroelectronic interfaces have enabled significant advances in both fundamental neuroscience research and the treatment of neurological disorders. However, current neuroelectronic devices have a clear trade-off between invasiveness and spatial resolution, and are unable to achieve seamless integration into the nervous system with cell-type specificity. In this talk, I will first introduce an ultra-small and […] |
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Abstract: This thesis addresses the fundamental questions surrounding the design and functional capabilities of enzyme-powered micromotors synthesized using microfluidic techniques. The research focuses on the development of these motors, made from artificial cell (protocell) scaffolds, and which seek to replicate the motion behavior of biological cells, investigating their propulsion mechanisms, motion directionality, and collective behavior. […] |
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Abstract DNA-binding proteins (DBPs) play critical roles in biology and biotechnology, and there has been considerable interest in the engineering of DBPs with new functions or altered specificities. While there has been success in reprogramming and the specificity of naturally occurring DBPs using selection methods, the computational design of new DBPs that engage with DNA […] |
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Learn how to commercialize your research and navigate Penn's innovation ecosystem with Penn Engineering: Entrepreneurship. This is the first part of a series from Penn Engineering’s Entrepreneurship group. Featuring: Andrew Tsourkas, Professor of Bioengineering, Co-Founder, AlphaThera, Inc, Co-Founder, StreamLaunch, Llc and Jeffrey Babin, Professor of Practice and Associate Director of Entrepreneurship at Penn Engineering & […] |
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