CBE

Abstract: Immunotherapies have achieved remarkable success in treating hematological cancers, yet the solid tumor microenvironment remains a significant barrier to therapeutic breakthroughs. Machine learning (ML)-driven computational protein design offers a powerful approach to creating novel protein components tailored for specific functions. By combining ML-driven design with synthetic biology and immuno-engineering, we have developed innovative tools […]

Abstract: Neurological conditions are the leading cause of illness worldwide, though over 92% of clinically tested CNS drug candidates fail to become treatments. Contributing to this high failure rate is a lack of understanding of human disease mechanisms, technologies to address them, and the restrictive blood-brain barrier (BBB), which most compounds fail to cross. New […]