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CBE Doctoral Dissertation Defense: “Bridging Transcription and Signaling to Study c-MYC Function and Regulation in Cancer Cells” (Reshma Kalyan Sundaram)
CBE Doctoral Dissertation Defense: “Bridging Transcription and Signaling to Study c-MYC Function and Regulation in Cancer Cells” (Reshma Kalyan Sundaram)
Abstract: The transcription factor c-MYC (MYC) is a master regulator of gene expression and is frequently deregulated in human cancers. Despite the prevalent role of MYC in cancers, no MYC inhibitors are currently available for clinical use. In this work, we investigated the molecular mechanisms underlying MYC’s transcriptional function and deregulation using an integrated approach […]