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BE Seminar: “Visualizing the Unseen: Enabling Precision Oncology Through Microenvironment-Triggered Diagnostics and Therapeutics” (Liangliang Hao)

Raisler Lounge (Room 225), Towne Building 220 South 33rd Street, Philadelphia, PA, United States

The successful integration of precision diagnostics with new personalized therapies opens numerous doors to improve the management of a variety of diseases. In cancer, tissue-environmental features of tumor progression and invasion, including aberrant extracellular matrix remodeling, stromal composition changes, and immune cell engagement, create engineering opportunities for use in developing novel biomarkers and therapeutic targets. […]

BE Seminar: “Orchestrating Cellular Regeneration at Organ Scale” (Yvon Woappi)

Large scale tissue damage, such as organ failure and burn injury, is a leading cause of morbidity and death. However, the mechanisms underlying full regeneration of organs remain poorly understood. As the largest organ system in the body, the integumentary system is a composite tissue assembly evolutionarily adapted for healing. Consequently, its complex physiology requires […]

BE Seminar: “From Bench to Pet-Side: Intratumoral Immunotherapy Principles and Practice” (Noor Momin)

216 Moore Building

Immunotherapies harness the body’s immune system to fight disease. Such therapies can help unleash an immune attack against diseased tissues but can inadvertently instigate an attack on healthy tissues. As a result, many promising immunotherapies face major toxicities, limiting their clinical use. By employing an iterative process that entails measuring, making, and modeling to manipulate […]

MSE Seminar: “Engineered Biomaterials for Regeneration, Therapy, and Beyond” Akhilesh K Gaharwar, Texas A&M University

Wu and Chen Auditorium (Room 101), Levine Hall 3330 Walnut Street, Philadelphia, PA, United States

Engineered biomaterials have emerged as powerful tools for a range of biomedical applications, including regenerative medicine, drug delivery, and additive manufacturing. These engineered biomaterials possess tunable biophysical properties, specific biochemical cues, and complex architecture, enabling precise control over cellular behavior. In this talk, I will outline three biomaterials-based approaches developed in our lab for biomedical […]

BE-Grace Hopper Distinguished Lecture: Melody Swartz, PhD “Immunoregulatory roles of lymphatic vessels in cancer and opportunities for immunoengineering”

Berger Auditorium (Room 13), Skirkanich Hall 210 South 33rd Street, Philadelphia, PA, United States

Tumor lymphangiogenesis, which involves both the activation and growth induction of surrounding lymphatic vessels, is well-known to correlate with tumor progression and metastasis in many solid tumors. While it is typically assumed that lymphangiogenesis supports an ‘escape route’ for cells to leave the primary tumor, the tumor-draining lymph node serves as the key site of […]

CBE Doctoral Dissertation Defense: “Bridging Transcription and Signaling to Study c-MYC Function and Regulation in Cancer Cells” (Reshma Kalyan Sundaram)

Raisler Lounge (Room 225), Towne Building 220 South 33rd Street, Philadelphia, PA, United States

Abstract: The transcription factor c-MYC (MYC) is a master regulator of gene expression and is frequently deregulated in human cancers. Despite the prevalent role of MYC in cancers, no MYC inhibitors are currently available for clinical use. In this work, we investigated the molecular mechanisms underlying MYC’s transcriptional function and deregulation using an integrated approach […]