The brain is a powerful organ that regulates health and drives intelligence. How can we see more clearly into the working brain to understand it better? High-resolution optical microscopy has long been an ideal tool due to its spatial sub-micron precision and specificity. However, achieving the necessary spatio-temporal scale for further advancing our understanding of […]
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Precise RNA expression, tailored to specific brain regions, cell types, and subcellular compartments, is pivotal for orchestrating complex brain functions. In the first part of my talk, I will introduce a confocal imaging-based spatial transcriptomics platform, STARmap, that seamlessly combines in situ hybridization, hydrogel tissue chemistry, and in situ sequencing technologies. Leveraging scalable experimental and computational pipelines, […] |
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The Department of Bioengineering at the University of Pennsylvania and Dr. Despina Kontos are pleased to announce the Doctoral Dissertation Defense of Apurva Singh. Title: "Computational imaging and multiomic biomarkers for precision medicine: characterizing heterogeneity in lung cancer" Date: February 12, 2024 Time: 1:00 PM Location: John Morgan Building, Class of 62 auditorium Zoom link The public is […] |
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Computers can be programmed for superhuman pattern recognition of images and text; however, their application in biology and medicine is still in its infancy. In this talk, I will discuss our advances over the past half-decade, which are accelerating discoveries in the crucial and underinvested area of antibiotic discovery. We developed the first antibiotic designed […] |
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Dr. Lu will introduce a fluorescence molecular imaging method to track therapeutic antibody delivery from cancer patients in vivo, down to single cells, through first-in-human clinical trials. She will present a new experimental and AI-powered analytical framework that integrates single-cell drug imaging with spatial omics to decipher drug-target-microenvironment in situ. This work establishes a foundational […] |
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Traditional biomedical imaging techniques face throughput bottlenecks that limit our ability to study complex dynamic samples like cells, organoids, tissues, and organisms. In particular, hardware-only systems have inherent physical limitations preventing the simultaneous improvement of resolution, field of view, and frame rate. In this seminar, I propose that large-scale, machine learning-accelerated computational imaging will be […]
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In this seminar, I explore the pivotal role of tissue stem cells and their microenvironment, known as the niche, in regeneration. With a focus on the endothelial cell niche, my work introduces an innovative in vitro vascularized perfusable model tailored for human tissue explants and organoids. My findings also highlight the crucial contribution of paracrine […] |
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The immune system uses a complex network of interacting cells that work together to regulate tissue physiology, homeostasis, and repair. In muscle, a tightly coordinated network of immunocytes and mesenchymal stromal cells (MSCs) is required for adequate skeletal muscle repair after acute injury or disease. Regulatory T cells (Tregs) are important players in regulating excessive […] |
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Learn how to commercialize your research and navigate Penn's innovation ecosystem with Penn Engineering: Entrepreneurship. This is the first part of a series from Penn Engineering’s Entrepreneurship group. Featuring: Andrew Tsourkas, Professor of Bioengineering, Co-Founder, AlphaThera, Inc, Co-Founder, StreamLaunch, Llc and Jeffrey Babin, Professor of Practice and Associate Director of Entrepreneurship at Penn Engineering & […] |
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