MSE Seminar: “Engineering nanoparticle-cell interactions: using a library-based approach to guide drug carrier design”

Nanoparticles offer huge promise as drug delivery vehicles, though their translation to the clinic is hampered due to limited accumulation at target disease sites. To overcome this hurdle, we have employed colloidal layer-by-layer assembly to generate comprehensive nanoparticle libraries to study the role of chemical composition in nanoparticle targeting, trafficking, and uptake. In this seminar, use of these libraries to study interactions with ovarian cancer cells and develop a new class of multifunctional drug carriers will first be discussed. Expansion of our library-based approach via the use of high throughput, pooled screening and correlative genomics will be detailed in the second half. Key underlying principles from these studies will be highlighted for their potential to influence future nanocarrier design.