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MEAM Seminar: “Micro-surgical Tools for Dissecting Cells and Tissues”
September 16, 2025 at 10:15 AM - 11:15 AM
Wound healing is an essential biological process for maintaining homeostasis and, ultimately, for survival. We investigate the mechanisms underlying extreme wound healing in Stentor coeruleus, a single-celled organism, capable of recovering from drastic membrane wounds exceeding half of the cell surface. This talk focuses on our recent effort on developing a microfluidic platform for the manipulation and reproducible wounding of the cell. We demonstrate a microfluidic “guillotine” for bisecting cells in a continuous flow, and a “SMORES” platform to immobilize the cells for laser ablation. We further discuss the extension of the tool for dissecting live tumors to generate organoids that preserve the tumor immune microenvironment for applications including the testing of immunotherapy on a chip.
Sindy Tang
Kenneth and Barbara Oshman Faculty Scholar and Associate Professor of Mechanical Engineering, Senior Fellow at the Woods Institute for the Environment and Professor, by courtesy, of Radiology and of Bioengineering, Stanford University
Prof. Sindy KY Tang is the Kenneth and Barbara Oshman Faculty Scholar and Associate Professor of Mechanical Engineering and by courtesy of Bioengineering and Radiology (Precision Health and Integrated Diagnostics) at Stanford University. She received her Ph.D. from Harvard University in Engineering Sciences. The micro-nano-bio lab under the direction of Prof. Tang aims to develop innovative micro and nanoscale devices that enable precise manipulation, measurement, and recapitulation of biological systems, in order to understand the “rules of life” and accelerate precision medicine and material design for a future with better health and environmental sustainability. Prof. Tang’s work has been recognized by multiple awards including the NSF CAREER Award, and invited lecture at the Nobel Symposium on Microfluidics in Sweden. Website: http://web.stanford.edu/group/tanglab/