MEAM Seminar: “Cuboids: A Microscale Cancer Model That Retains Key Features of the Tumor Microenvironment”
April 21 at 10:15 AM - 11:15 AM
There is a lack of confidence in present in vitro disease models and drug efficacy tests, as they do not properly recapitulate the dynamic physiology and pathophysiology of the human organism. This challenge is particularly acute in oncology: present tools to study drug responses fail to faithfully mimic the patient’s tumor microenvironment (TME) and thus have not kept up with tumor biology and drug testing needs. As a measure of this problem, on average less than 4% of oncology drugs in clinical trials end up being FDA-approved, a dismal approval rate that has dire social repercussions such as high cancer drug prices and difficult accessibility. We have developed a suite of microfluidic platforms that address this problem by multiplexing the delivery of drugs to intact-TME human biopsies, altogether bypassing animal testing. We have developed and patented a microdissection methodology that allows for producing large numbers of regularly-sized, cuboidal micro-tissues (“cuboids”) from a single tumor biopsy. We have developed arrays of microfluidic traps for cuboid perfusion and a very high-throughput automated robotic placement of mouse and human cuboids in 384-well plates. With these approaches, it will soon be possible to bypass animal testing and perform direct testing of drugs using only human tumors. Since these new-generation tests preserve the TME intact, we envision that they will minimize FDA failure rates and will contribute to alleviate the cost of cancer drugs. In this talk, I will also cover innovative 3D printing approaches of general applicability to the fabrication of complex biomicrofluidic systems such as organs-on-chips.
Albert Folch
Professor, Department of Bioengineering, University of Washington
Albert Folch’s lab works at the interface between microfluidics and cancer. He received both his BSc (1989) and PhD (1994) in Physics from the University of Barcelona (UB), Spain, in 1989. During his Ph.D. he was a visiting scientist from 1990–91 at the Lawrence Berkeley Lab working on AFM/STM under Dr. Miquel Salmeron. From 1994–1996, he was a postdoc at MIT developing MEMS under Martin Schmidt (EECS) and Mark Wrighton (Chemistry). In 1997, he joined Mehmet Toner’s lab as a postdoc at Harvard-MGH to apply soft lithography to tissue engineering. He has been at Seattle’s UW BioE since June 2000, where he is now a full Professor, accumulating over 15,000 citations (h-index 55; career average 150 citations/paper). In 25 years, he has graduated 20 postdocs (20% of whom have reached faculty rank) and 33 graduate students (11 Ph.D. students, 27% of whom faculty rank, and 22 M.S. students).
In 2001 he received an NSF Career Award, and in 2014 he was elected to the AIMBE College of Fellows (Class of 2015). He serves on the Advisory Board of Lab on a Chip since 2010 and on the Editorial Board of Micromachines since 2019. In 2022 he was elected a member of the Institute for Catalan Studies, one of the highest honors bestowed on Catalan scientists.
He is the author of 6 books (sole author), including Introduction to BioMEMS (2012, Taylor&Francis), a textbook adopted by >107 departments in 18 countries, Hidden in Plain Sight: The History, Science, and Engineering of Microfluidic Technology (MIT Press, 2022, winner of the 2022 Outstanding Academic Title Award by Choice), and the recent How the World Flows: Microfluidics from Raindrops to Covid Tests (Oxford University Press, 2025, featured in New Scientist). Since 2007, the lab runs a celebrated outreach art program called BAIT (Bringing Art Into Technology), which has produced eight exhibits, a popular resource gallery of >2,000 free images related to microfluidics and microfabrication, and a YouTube channel that plays microfluidic videos with music that accumulate >179,000 visits since 2009.