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Cancelled: CBE Seminar – Biomaterials-Mediated Inflammation Control”

April 22, 2020 at 3:00 PM - 4:00 PM

Abstract:

Many chronic disabling diseases such as rheumatoid arthritis, psoriasis, multiple sclerosis and systemic lupus erythematosus are increasingly linked to inappropriate and chronic activation of inflammatory cells. A central event in the pathogenesis of these diseases appears to be an aberrant activation of innate immune sensors, most prominently the Pattern Recognition Receptors (PRRs), by nucleic acids that are released from dead and dying cells. Moreover, such extracellular nucleic acids have also been implicated in inflammatory diseases such as heart attack, traumatic injury, and stroke in activating the contact pathway of coagulation. In this presentation, I will discuss the application of nucleic acid-binding polymers in the configuration of either soluble or immobilized polycation to scavenge these pathogenic nucleic acids as a molecular strategy to combat inflammation.

Kam W. Leong

Samuel Y. Sheng Professor of Biomedical Engineering, Columbia University

Kam W. Leong is the Samuel Y. Sheng Professor of Biomedical Engineering at Columbia University. He received his Ph.D. in Chemical Engineering from the University of Pennsylvania. After serving as a faculty in the Department of Biomedical Engineering at The Johns Hopkins School of Medicine for almost 20 years, he moved to Duke University in 2006 to focus on the design of nanostructures for therapeutic applications. After moving to Columbia University in September 2014, he continues to work on nanoparticle-mediated, non-viral gene delivery and gene editing. He has published ~400 peer-reviewed papers and holds more than 60 issued patents. His work has been recognized by a Young Investigator Research Achievement Award of the Controlled Release Society, Distinguished Scientist Award of the International Journal of Nanomedicine, Clemson Award for Applied Research of the Society for Biomaterials, and Lifetime Achievement Award of CASNN. He is the Editor-in-Chief of Biomaterials, a member of Academia Sinica, the International Institute of Medical and Biological Engineering, the USA National Academy of Inventors, and the USA National Academy of Engineering.

Details

Date:
April 22, 2020
Time:
3:00 PM - 4:00 PM
Event Category:
Event Tags:
Website:
https://cbe.seas.upenn.edu/events/

Organizer

Chemical and Biomolecular Engineering
Phone:
215-898-8351
Email:
chebiom@seas.upenn.edu
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Venue

Wu and Chen Auditorium (Room 101), Levine Hall
3330 Walnut Street
Philadelphia, PA 19104 United States
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