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CBE PhD Dissertation Defense | “3D-stiffness Microenvironment Leads to Nuclear Envelope Rupture, DNA Damage, and Genome Variation”
CBE PhD Dissertation Defense | “3D-stiffness Microenvironment Leads to Nuclear Envelope Rupture, DNA Damage, and Genome Variation”
Abstract: "Solid tumor cells grow in a stiff microenvironment with dense extracellular matrix (ECM) and condensed packing of adjacent cells. Tumor cells are capable of migrating through constricted pores formed by ECM or surrounded by other cells, and the nuclear envelope can break with repair factor mislocalization, further leading to DNA damage and genetic changes, […]