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CBE PhD Dissertation Defense | Establishing the Transient Mass Balance of Thrombosis Under Venous Flow: From A Microfluidic Approach To A Reduced Model
CBE PhD Dissertation Defense | Establishing the Transient Mass Balance of Thrombosis Under Venous Flow: From A Microfluidic Approach To A Reduced Model
Abstract: Coagulation kinetics are well established in well plates assays in which human plasma clots isotropically. However, less is known about thrombin kinetics and transport within clots formed under hemodynamic flow. Using microfluidic perfusion of Factor XIIa-inhibited human whole blood over a 250-micron long patch of collagen/tissue factor and immunoassays of the effluent for fragment […]